Volume 34, No 6, Jun 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 6, June 2024: 397-398

RESEARCH HIGHLIGHTS

ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb

Song Li^1,† , Xinxing Ouyang^1,2,† , Bing Su^1,3,4,*

¹Shanghai Institute of Immunology, Department of Immunology and Microbiology at Basic Medical College, Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Shanghai Chest Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Department of Gastroenterology and Center for Immune-Related Diseases Research at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁴Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China
^†These authors contributed equally: Song Li, Xinxing Ouyang
Correspondence: Bing Su(bingsu@sjtu.edu.cn)

A new study from Feng et al. developed an improved proximity labeling technology called PhastID and successfully identified the lysosomal v-ATPase subunit ATP6AP1 as an unconventional guanine nucleotide exchange factor for Rheb, a key positive regulator of mTORC1. ATP6AP1 binds directly to Rheb via a highly conserved C-terminal segment to promote its GTP loading and mTORC1 activation.

https://doi.org/10.1038/s41422-024-00967-8

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