Volume 34, No 9, Sep 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 9, September 2024: 599-600

RESEARCH HIGHLIGHTS

Piecing together aminergic polypharmacology

Blake A. Fordyce , Bryan L. Roth^*

Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA
Correspondence: Bryan L. Roth(bryan_roth@med.unc.edu)

Neuropsychiatric medications are often designed to have affinity for multiple ligand-binding sites across different receptor types to increase therapeutic efficacy. In a recent paper in Cell, Chen and colleagues implement a flexible scaffold-based cheminformatics approach to design bi-target therapeutics for dementia-related psychosis.

https://doi.org/10.1038/s41422-024-00970-z

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