Volume 34, No 10, Oct 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 10, October 2024: 681-682

RESEARCH HIGHLIGHTS

Illuminating the path to pancreatic cancer

Hiroyuki Kato^1,2,3 , Nabeel Bardeesy^1,2,3,*

¹Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
²Department of Medicine, Harvard Medical School, Boston, MA, USA
³Broad Institute of MIT and Harvard, Cambridge, MA, USA
Correspondence: Nabeel Bardeesy(bardeesy.nabeel@mgh.harvard.edu)

Braxton and colleagues used 3D histological reconstruction and multi-region genomic analysis to understand the microanatomy and model the progression of pancreatic intraepithelial neoplasias (PanINs), precursors of pancreatic ductal adenocarcinoma (PDAC). Their study revealed the unexpected prevalence, spatial distribution, and genetic heterogeneity of PanINs, illuminating their developmental trajectories toward PDAC.

https://doi.org/10.1038/s41422-024-00982-9

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