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Volume 34, No 10, Oct 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 10, October 2024: 679-680

RESEARCH HIGHLIGHTS

All-in-one Hangzhou Protocol: killing four birds with one stone

Haopeng Wang1,2,3,†,* , Shizhen Qiu1,4,† , Mohamad Mohty5,*

1School of Life Science and Technology, ShanghaiTech University, Shanghai, China
2State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China
3Shanghai Clinical Research and Trial Center, Shanghai, China
4Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
5Department of Clinical Hematology and Cellular Therapy, Saint-Antoine Hospital, AP-HP, Sorbonne University, and INSERM, Saint-Antoine Research Centre, Paris, France
These authors contributed equally: Haopeng Wang, Shizhen Qiu
Correspondence: Haopeng Wang(wanghp@shanghaitech.edu.cn)Mohamad Mohty(mohamad.mohty@inserm.fr)

In a recent study published in The New England Journal of Medicine, researchers developed an innovative “all-in-one” treatment protocol that combines CD7 chimeric antigen receptor T-cell therapy with subsequent haploidentical hematopoietic stem cell transplantation. This approach significantly advances the treatment of CD7+ hematological malignancies by eliminating the need for myeloablative chemotherapy and immunosuppressants for graft-versus-host disease prophylaxis.


https://doi.org/10.1038/s41422-024-00983-8

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