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Submit Manuscript Volume 34, No 10, Oct 2024
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 34 Issue 10, October 2024: 677-678
Tumor microenvironment squeezes out the juice from T cells
Romane Thouenon1,2 , Grégory Verdeil1,2,*
1Department of Oncology UNIL CHUV, University of Lausanne, Vaud, SwitzerlandEscaping the immune response is a major prerequisite for tumor to emerge and progress, and many different mechanisms are in place within the tumor microenvironment (TME) to reach this aim, including the induction of CD8+ T cell exhaustion. In a recent publication in Cell, Zhang and colleagues showed that biomechanical stress occurring in the TME enforces CD8+T cell exhaustion through the expression of the transcription factor Osr2 that acts as an epigenetic regulator.
https://doi.org/10.1038/s41422-024-00987-4