Volume 34, No 10, Oct 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 10, October 2024: 677-678

RESEARCH HIGHLIGHTS

Tumor microenvironment squeezes out the juice from T cells

Romane Thouenon^1,2 , Grégory Verdeil^1,2,*

¹Department of Oncology UNIL CHUV, University of Lausanne, Vaud, Switzerland
²Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland
Correspondence: Grégory Verdeil(gregory.verdeil@unil.ch)

Escaping the immune response is a major prerequisite for tumor to emerge and progress, and many different mechanisms are in place within the tumor microenvironment (TME) to reach this aim, including the induction of CD8+ T cell exhaustion. In a recent publication in Cell, Zhang and colleagues showed that biomechanical stress occurring in the TME enforces CD8+T cell exhaustion through the expression of the transcription factor Osr2 that acts as an epigenetic regulator.

https://doi.org/10.1038/s41422-024-00987-4

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