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Submit Manuscript Volume 34, No 10, Oct 2024
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 34 Issue 10, October 2024: 675-676
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
Ella Hartenian , Petr Broz*
Department of Immunobiology, University of Lausanne, Epalinges, SwitzerlandGasdermin D (GSDMD) is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation. In a recent study in Nature, Du et al. report that S-palmitoylation of human GSDMD at Cys191 (mouse Cys192) is a key regulatory step that controls both its activation and interaction with membranes.
https://doi.org/10.1038/s41422-024-00988-3