Volume 34, No 10, Oct 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 10, October 2024: 675-676

RESEARCH HIGHLIGHTS

Pyroptosis: palmitoylation regulates GSDMD activation and pore formation

Ella Hartenian , Petr Broz^*

Department of Immunobiology, University of Lausanne, Epalinges, Switzerland
Correspondence: Petr Broz(petr.broz@unil.ch)

Gasdermin D (GSDMD) is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation. In a recent study in Nature, Du et al. report that S-palmitoylation of human GSDMD at Cys191 (mouse Cys192) is a key regulatory step that controls both its activation and interaction with membranes.

https://doi.org/10.1038/s41422-024-00988-3

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