Volume 34, No 8, Aug 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 8, August 2024: 535-536

RESEARCH HIGHLIGHTS

ANT2: the first mammalian mitochondrial RNA transport translocon

Huanhuan Zhu¹ , Weiqiang Lin^2,* , Aifu Lin^2,3,*

¹Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
²International Institutes of Medicine, International School of Medicine, The Fourth Affiliated Hospital of School of Medicine, Zhejiang University, Yiwu, Zhejiang, China
³College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
Correspondence: Weiqiang Lin(wlin@zju.edu.cn)Aifu Lin(linaifu@zju.edu.cn)

Despite the crucial roles of mitochondrial RNA transport in maintaining mitochondrial functionality, how mitochondrial RNAs are transported across mitochondrial membranes remains largely unknown. In a recent work published in Cell Research, Wang et al. identified adenine nucleotide translocase-2 as the first mammalian mitochondrial RNA translocon using a series of innovative biochemical systems and revealed its regulatory role in innate immunity triggered by mitochondrial double-stranded RNA efflux.

https://doi.org/10.1038/s41422-024-00994-5

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