Volume 34, No 11, Nov 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 11, November 2024: 751-752

RESEARCH HIGHLIGHTS

Painful memories boost protective immunity

Tri Giang Phan^1,2,* , Elissa K. Deenick^1,3,*

¹Precision Immunology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
²St Vincent’s Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia
³Kirby Institute, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia
Correspondence: Tri Giang Phan(t.phan@garvan.org.au)Elissa K. Deenick(e.deenick@garvan.org.au)

How does pain, induced by inflammation, an innate immune response to tissue injury, impact humoral immunity, an adaptive immune response to infection? In a recent study in Cell, Wu et al. show that TRPV1+ nociceptive sensory neurons detect the inflammatory lipid mediator PGE2 and release CGRP to activate the CALCRL/RAMP1 heterodimeric receptor, adenylate cyclase and cAMP signaling on B cells to boost the humoral immune response.

https://doi.org/10.1038/s41422-024-01002-6

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