Volume 34, No 12, Dec 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 12, December 2024: 826-827

RESEARCH HIGHLIGHTS

Rejuvenating immunity through a balancing stem cell act

Sten Eirik W. Jacobsen^1,2,*

¹Department of Cell and Molecular Biology and Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
²Haematopoietic Stem Cell Biology Laboratory and MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Correspondence: Sten Eirik W. Jacobsen(sten.eirik.jacobsen@ki.se)

An alteration in the lineage bias of aged hematopoietic stem cells (HSCs) has been implicated in the reduced immunity observed upon aging. Ross and colleagues now provide direct support for this hypothesis, demonstrating that a selective depletion of myeloid-biased HSCs in aged mice is accompanied by improvement in several parameters of immunity, uncovering a possible novel therapeutic avenue for counteracting age-related decline in immunity.

https://doi.org/10.1038/s41422-024-01005-3

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