Volume 34, No 12, Dec 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 12, December 2024: 828-829

RESEARCH HIGHLIGHTS

Yin and Yang of innate immune cell death

Yaqiu Wang , Thirumala-Devi Kanneganti^*

Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Correspondence: Thirumala-Devi Kanneganti(Thirumala-Devi.Kanneganti@StJude.org)

Lytic innate immune cell death releases a variety of pathogen-associated and damage-associated molecular patterns, cytokines, metabolites and other molecules into the extracellular environment, where they can drive further physiological responses. In a recent study in Nature, Mehrotra et al. studied the secretome released during NLRP1B inflammasome-driven pyroptosis and identified that metabolites released by dying cells can promote wound healing.

https://doi.org/10.1038/s41422-024-01007-1

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