Volume 35, No 1, Jan 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 1, January 2025: 3-4

RESEARCH HIGHLIGHTS

Deciphering the role of immune system in the obesity–cancer relationship

Camille Blériot^1,2 , Gerasimos Anagnostopoulos¹ , Florent Ginhoux^1,3,4,5,*

¹Gustave Roussy, CNRS, INSERM, Villejuif, France
²Institut Necker Enfants Malades (INEM), CNRS, INSERM, Université Paris Cité, Paris, France
³Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore
⁴Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁵Translational Immunology Institute, SingHealth Duke-NUS, Singapore, Singapore
Correspondence: Florent Ginhoux(florent.ginhoux@gustaveroussy.fr)

Obesity and its associated meta-inflammation lead to metabolic and functional reprogramming of immune cells. In a recent Nature paper, Bader et al. show that obesity selectively induced PD-1 expression on tumor-associated macrophages, which triggers a feedback mechanism impairing tumor immune surveillance by notably metabolically reprogramming cytotoxic T cells.

https://doi.org/10.1038/s41422-024-01008-0

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