Volume 35, No 2, Feb 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 2, February 2025: 91-92

RESEARCH HIGHLIGHTS

Stroke-induced trained immunity spells bad news for the heart

George Hajishengallis^1,* , Triantafyllos Chavakis²

¹Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
²Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Correspondence: George Hajishengallis(geoh@upenn.edu)

Inflammatory memory in the bone marrow has been proposed as a common mechanistic basis driving the emergence of comorbidities. In a recent Cell paper, Simats et al. show that stroke-induced inflammation causes persistent inflammatory memory in hematopoietic progenitors that give rise to hyper-inflammatory monocytes that infiltrate the heart and promote cardiac dysfunction.

https://doi.org/10.1038/s41422-024-01018-y

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