Volume 35, No 2, Feb 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 2, February 2025: 93-94

RESEARCH HIGHLIGHTS

Preservation of a youthful path to evergreen platelets?

Sten Eirik W. Jacobsen^1,2,*

¹Department of Cell and Molecular Biology and Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
²Haematopoietic Stem Cell Biology Laboratory and MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Correspondence: Sten Eirik W. Jacobsen(sten.eirik.jacobsen@ki.se)

The enhanced myeloid lineage bias of old hematopoietic stem cells (HSCs) has been implicated to underpin the compromised immunity observed upon aging. In a recent paper in Cell, Poscablo and coworkers now present experimental support for also the dysregulated function of platelets seen during aging, emanating at the aged HSC level; they identified an aging- and platelet-specific differentiation pathway in mice, which, compared to the canonical pathway dominating in young mice, replenishes megakaryocyte progenitors which with faster kinetics and enhanced regenerative potential produce hyper-reactive platelets.

https://doi.org/10.1038/s41422-024-01015-1

FULL TEXT | PDF

Browse 312