Volume 35, No 2, Feb 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 2, February 2025: 95-96

RESEARCH HIGHLIGHTS

PDK1 neddylation by Smurf1 drives Akt activation

Rajesh Kumar Manne^1,† , Rajni Kant^1,† , Hui-Kuan Lin^1,*

¹Department of Pathology, School of Medicine, Duke University, Durham, NC, USA
^†These authors contributed equally: Rajesh kumar Manne, Rajni Kant
Correspondence: Hui-Kuan Lin(hui-kuan.lin@duke.edu)

The PI3K/Akt pathway, one of the most frequently dysregulated signaling pathways in various cancers, plays a key role in tumorigenesis and resistance to chemotherapy. Recent discovery highlights an important regulatory step where Smurf1-mediated PDK1 neddylation through poly-Nedd8 chains is an early event for oncogenic Akt activation in KRAS-mutant colorectal cancer.

https://doi.org/10.1038/s41422-024-01020-4

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