Volume 34, No 12, Dec 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 12, December 2024: 820-821

RESEARCH HIGHLIGHTS

Designing de novo D-protein binders

Haiyan Liu^*

School of Life Sciences, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China
Correspondence: Haiyan Liu(hyliu@ustc.edu.cn)

D-proteins hold considerable potential in biotechnological applications because of their generally anticipated higher bioorthogonality and stability over L-proteins. In a recent paper in Cell Research, Sun and colleagues demonstrated the successful design of de novo D-proteins that selectively bind to specific target regions of natural L-proteins or L-peptides.

https://doi.org/10.1038/s41422-024-01029-9

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