Volume 34, No 11, Nov 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 11, November 2024: 759-760

RESEARCH HIGHLIGHTS

Lysine methylation steps into another step of the central dogma

Zuodong Zhao¹ , Bing Zhu^1,2,3,*

¹Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
²New Cornerstone Science Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
³College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China
Correspondence: Bing Zhu(zhubing@ibp.ac.cn)

Lysine methylation is an important protein modification that regulates replication and transcription, the fundamental events of the central dogma. However, whether it plays a role in translation, the last step of the central dogma, remains unclear. Two recent studies revealed that lysine methyltransferase SMYD5 catalyzes the trimethylation of lysine 22 in ribosomal protein RPL40, enhances translation output, and promotes cancer progression.

https://doi.org/10.1038/s41422-024-01033-z

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