Volume 35, No 2, Feb 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 2, February 2025: 89-90

RESEARCH HIGHLIGHTS

Knowing when to stop: MICL self-regulates neutrophil NETosis

Hanjoo Brian Shim^1,2 , Justin François Deniset^1,2,3,4,† , Paul Kubes^1,2,5,†,*

¹Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
²Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada
³Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada
⁴Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada
⁵Department of Biomedical and Molecular Science, Queen’s University, Kingston, ON, Canada
^†These authors contributed equally: Justin François Deniset, Paul Kubes
Correspondence: Paul Kubes(p.kubes@queensu.ca)

In a recent study published in Nature, Malamud et al. identified how neutrophil MICL recognizes neutrophil extracellular traps (NETs). This recognition suppresses further neutrophil activation and NET production, thereby preventing a vicious cycle of inflammation.

https://doi.org/10.1038/s41422-024-01037-9

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