Volume 35, No 4, Apr 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 4, April 2025: 233-234

RESEARCH HIGHLIGHTS

Stressing out the intestinal microbiota via a brain-neuroglandular circuit

Wen Zhang^1,2,3,4,5,* , David Artis^1,2,3,4,5,*

¹Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA
²Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA
³Division of Gastroenterology and Hepatology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA
⁴Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA
⁵Allen Discovery Center for Neuroimmune Interactions, Weill Cornell Medicine, Cornell University, New York, NY, USA
Correspondence: Wen Zhang(wez4002@med.cornell.edu)David Artis(dartis@med.cornell.edu)

A new study published in Cell identifies a stress-sensitive brain-neuroglandular circuit that regulates the intestinal microbiota and systemic host immunity. Chronic stress inhibits the duodenal gland activity, which drives intestinal dysbiosis and impaired host immunity to pathogens.

https://doi.org/10.1038/s41422-024-01047-7

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