Volume 35, No 4, Apr 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 4, April 2025: 237-238

RESEARCH HIGHLIGHTS

Triaptosis: an endosome-dependent cell death modality

Daolin Tang^1,* , Rui Kang¹ , Guido Kroemer^2,3,4,*

¹Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
²Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France
³Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France
⁴Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
Correspondence: Daolin Tang(daolin.tang@utsouthwestern.edu)Guido Kroemer(kroemer@orange.fr)

Recent research published in Science reveals that menadione, a precursor to vitamin K, induces a unique cell death pathway called triaptosis by oxidizing phosphatidylinositol 3-kinase PIK3C3/VPS34. This oxidation leads to endosomal dysfunction, highlighting how excessive oxidative stress can compromise cellular structures and activate specific cell death pathways.

https://doi.org/10.1038/s41422-024-01053-9

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