Volume 35, No 4, Apr 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 4, April 2025: 239-240

RESEARCH HIGHLIGHTS

Tug of war between phosphatase and kinase during sleep

Niels Niethard^1,2,* , Jan Born^1,3,4,5,6,*

¹Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
²Department of Cognitive Sciences, University of California, Irvine, Irvine, CA, USA
³German Center for Diabetes Research (DZD), Tübingen, Germany
⁴Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Center Munich at the University Tübingen (IDM), Tübingen, Germany
⁵German Center for Mental Health (DZPG), Tübingen, Germany
⁶Werner Reichert Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany
Correspondence: Niels Niethard(niels.niethard@uni-tuebingen.de)Jan Born(jan.born@uni-tuebingen.de)

In a recent work published in Nature, Wang et al. reveal how protein kinase A and calcineurin dynamically regulate the daily duration of sleep and wake periods at excitatory post-synapses in the brain. This study uncovers key molecular mechanisms offering new insights into the enzymatic control of sleep homeostasis.

https://doi.org/10.1038/s41422-024-01065-5

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