Volume 35, No 4, Apr 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 4, April 2025: 241-242

RESEARCH HIGHLIGHTS

Astrocytes: emerging stars of engrams

Sofiya Zbaranska^1,2 , Sheena A. Josselyn^1,2,3,*

¹Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada
²Department of Physiology, University of Toronto, Toronto, ON, Canada
³Department of Psychology, University of Toronto, Toronto, ON, Canada
Correspondence: Sheena A. Josselyn(sheena.josselyn@sickkids.ca)

During learning experience, a subset of astrocytes in the hippocampus is activated and becomes both necessary and sufficient for subsequent memory recall. Williamson et al. discovered that these learning-associated astrocytes play an important role in memory by modulating engram neurons’ synaptic activity and facilitating the reactivation of engram neuron ensembles during memory retrieval.

https://doi.org/10.1038/s41422-024-01066-4

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