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Volume 35, No 1, Jan 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 1, January 2025: 1-2

RESEARCH HIGHLIGHTS

Tau(t)ing glucocorticoid binding

Sabine Vettorazzi , Jan Tuckermann*

Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Baden-Württemberg, Germany
Correspondence: Jan Tuckermann(jan.tuckermann@uni-ulm.de)

Glucocorticoids are two-faced drugs: they have beneficial anti-inflammatory effects but, on the other hand, trigger complications like osteoporosis; identifying glucocorticoid-mediated pathways responsible for side effects, while maintaining their anti-inflammatory action, has been a long-standing goal. Fu et al. discovered that Tau acts as a low-affinity glucocorticoid receptor to induce bone resorption.


https://doi.org/10.1038/s41422-024-01041-z

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