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Submit Manuscript Volume 35, No 1, Jan 2025
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 35 Issue 1, January 2025: 5-6
LKB1 inactivation unleashes prostate cancer lineage plasticity
Shaghayegh Nouruzi1,2 , Amina Zoubeidi1,2,*
1Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, CanadaWhile it is well established that androgen receptor pathway inhibition leads to the development of double-negative prostate cancer (DNPC), the mechanisms underlying this cell fate decision remain unclear. In a recent study published in Cell Research, Li et al. identified that LKB1 inactivation supports the development of DNPC through metabolic and epigenetic rewiring, highlighting DNA hypomethylation as a vulnerability and TET2/3 as potential therapeutic targets.
https://doi.org/10.1038/s41422-024-01030-2