Advanced Search
Submit Manuscript Advanced Search
Submit Manuscript
Volume 35, No 1, Jan 2025
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 35 Issue 1, January 2025: 45-48 |
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Yuting Wang1,2,3 , Wenhao Zhang1,2,3 , Chao Zhang1,2,3 , Hoang Q. Tran Van1,2,3 , Takashi Seino1,2,3 , Yi Zhang1,2,3,4,5,*
1Howard Hughes Medical Institute, Boston Children’s Hospital, Boston, MA, USAAging is a process accompanied by functional decline in tissues and organs with great social and medical consequences. Developing effective anti-aging strategies is of great significance. In this study, we demonstrated that transplantation of young hematopoietic stem cells (HSCs) into old mice can mitigate aging phenotypes, underscoring the crucial role of HSCs in the aging process. Through comprehensive molecular and functional analyses, we identified a subset of HSCs in aged mice that exhibit “younger” molecular profiles and functions, marked by low levels of CD150 expression. Mechanistically, CD150low HSCs from old mice but not their CD150high counterparts can effectively differentiate into downstream lineage cells. Notably, transplantation of old CD150low HSCs attenuates aging phenotypes and prolongs lifespan of elderly mice compared to those transplanted with unselected or CD150high HSCs. Importantly, reducing the dysfunctional CD150high HSCs can alleviate aging phenotypes in old recipient mice. Thus, our study demonstrates the presence of “younger” HSCs in old mice, and that aging-associated functional decline can be mitigated by reducing dysfunctional HSCs.
https://doi.org/10.1038/s41422-024-01057-5
