Advanced Search

Submit Manuscript

Volume 35, No 8, Aug 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 8, August 2025: 547-548

RESEARCH HIGHLIGHTS

Neoself-antigen presentation in SLE: Mordred’s coronation in Arthur’s absence

Mehrdad Pazhouhandeh1 , Hongjian Sun1 , Di Yu1,2,*

1Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia
2Ian Frazer Centre for Children’s Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia
Correspondence: Di Yu(di.yu@uq.edu.au)

In a recent study led by Dr. Hisashi Arase published in Cell, a new mechanism underlying the breakdown of self-tolerance in systemic lupus erythematosus was reported that autoreactive T cells recognize neoself-antigens. Neoself-antigens, encompassing a range of self-molecules, were shown to be presented on major histocompatibility complex class II by non-canonical mechanisms following the downregulation of the invariant chain protein.


https://doi.org/10.1038/s41422-024-01052-w

FULL TEXT | PDF

Browse 273