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Submit Manuscript Volume 35, No 8, Aug 2025
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 35 Issue 8, August 2025: 547-548
Neoself-antigen presentation in SLE: Mordred’s coronation in Arthur’s absence
Mehrdad Pazhouhandeh1 , Hongjian Sun1 , Di Yu1,2,*
1Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD, AustraliaIn a recent study led by Dr. Hisashi Arase published in Cell, a new mechanism underlying the breakdown of self-tolerance in systemic lupus erythematosus was reported that autoreactive T cells recognize neoself-antigens. Neoself-antigens, encompassing a range of self-molecules, were shown to be presented on major histocompatibility complex class II by non-canonical mechanisms following the downregulation of the invariant chain protein.
https://doi.org/10.1038/s41422-024-01052-w