Volume 35, No 2, Feb 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 2, February 2025: 87-88

RESEARCH HIGHLIGHTS

Intrathymic alloantigen expression—the Holy Grail or reinventing the wheel?

Gavin J. Pettigrew^*

Department of Surgery, University of Cambridge, Cambridge, UK
Correspondence: Gavin J. Pettigrew(gjp25@cam.ac.uk)

In clinical solid organ transplantation, strategies that achieve long-term immunosuppression-free graft survival without the need for intense myeloablative conditioning remain elusive. In this issue of Cell Research, Liu et al. report that in murine transplant model, central deletional tolerance achieved by transduction of donor MHC alloantigen expression on the recipient thymus results in long-term skin allograft survival.

https://doi.org/10.1038/s41422-024-01067-3

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