Volume 35, No 3, Mar 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 3, March 2025: 155-156

RESEARCH HIGHLIGHTS

The non-canonical proteome: a novel contributor to cancer proliferation

Jorge Ruiz-Orera¹ , Norbert Hübner^1,2,3,4,*

¹Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
²DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany
³Charité-Universitätsmedizin, Berlin, Germany
⁴Helmholtz Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany
Correspondence: Norbert Hübner(nhuebner@mdc-berlin.de)

The non-canonical proteome, comprising hundreds of unannotated peptides encoded by small open reading frames, significantly expands the functional landscape of our genome beyond conventional protein-coding genes. Recent work by Shi et al. published in Cell Research combines several detection techniques and functional validations to explore this uncharted territory, and shows that more than a thousand of these small peptides play significant roles in tumor cell growth, offering new insights into cancer biology.

https://doi.org/10.1038/s41422-024-01069-1

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