Volume 35, No 5, May 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 5, May 2025: 328-329

RESEARCH HIGHLIGHTS

Chemogenetics for sensing antigens

Blake A. Fordyce , Bryan L. Roth^*

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Correspondence: Bryan L. Roth(bryan_roth@med.unc.edu)

Antigen-based systems offer highly specific binding and customizability, broadening their application to various fields of cell biology. In a recent issue of Nature, Kalogriopoulos et al. design antigen-sensing G-protein-coupled receptors that exhibit programmable responses spanning exogenous gene expression, G-protein signaling, and receptor activation.

https://doi.org/10.1038/s41422-025-01072-0

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