Volume 35, No 3, Mar 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 3, March 2025: 159-160

RESEARCH HIGHLIGHTS

Metabolite is a part of immune-regulating circuit

Han Wang¹ , Shi-Min Zhao^1,2,*

¹Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
²Institute of Metabolism & Integrative Biology, Fudan University, Shanghai, China
Correspondence: Shi-Min Zhao(zhaosm@fudan.edu.cn)

Metabolites play a critical role in regulating cell signaling by interacting with proteins either noncovalently or covalently, with spontaneous modifications being less understood. In a recent Cell Research study, Zhao et al. report that the accumulation of S-d-lactoylglutathione upon NF-κB activation induces spontaneous lysine d-lactylation, a process essential for maintaining immune homeostasis and appropriate host defense.

https://doi.org/10.1038/s41422-025-01074-y

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