Volume 35, No 3, Mar 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 3, March 2025: 157-158

RESEARCH HIGHLIGHTS

Halt aging? — functional HSCs lead the way

Rebecca T. Chu^1,2 , Adam B. Schroer¹ , Saul A. Villeda^1,2,3,4,*

¹Department of Anatomy, University of California San Francisco, San Francisco, CA, USA
²Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA
³Department of Physical Therapy and Rehabilitation Science, San Francisco, CA, USA
⁴Bakar Aging Research Institute, San Francisco, CA, USA
Correspondence: Saul A. Villeda(saul.villeda@ucsf.edu)

The aged immune system contributes to systemic aging, serving as a driver of morbidity and mortality in the elderly. In a recent Cell Research paper, Wang et al. identified both resilient and dysfunctional subsets of old hematopoietic stem cells (HSCs), of which selective reduction of dysfunctional old HSCs ameliorates aging phenotypes and extends lifespan in mice.

https://doi.org/10.1038/s41422-025-01079-7

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