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Volume 35, No 8, Aug 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 8, August 2025: 545-546

RESEARCH HIGHLIGHTS

New insights into how parental worms protect their offspring

Chenming Zeng , Eric A. Miska*

Department of Biochemistry, University of Cambridge, Cambridge, UK
Correspondence: Eric A. Miska(eam29@cam.ac.uk)

Parental exposure of Caenorhabditis elegans to pathogens can protect offspring against similar threats, but the bacterial cues and intergenerational signals underlying this response remain poorly understood. A recent study in Cell revealed a novel mechanism of intergenerational protection against natural pathogens, facilitated by the cyanoalanine synthase CYSL-2 and its detoxification intermediate.


https://doi.org/10.1038/s41422-025-01094-8

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