Volume 35, No 5, May 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 5, May 2025: 322-323

RESEARCH HIGHLIGHTS

Broad H3K4me3 domains orchestrate temporal control of gene expression

Yuka Kitamura^1,† , Mengwen Hu^1,† , Satoshi H. Namekawa^1,*

¹Department of Microbiology and Molecular Genetics, University of California, Davis, CA, USA
^†These authors contributed equally: Yuka Kitamura, Mengwen Hu
Correspondence: Satoshi H. Namekawa(snamekawa@ucdavis.edu)

Spermatogenesis is a highly coordinated developmental process during which precise temporal control of gene expression is crucial. In a recent study published in Cell Research, Lin et al. systematically profiled the epigenomic landscapes of male germ cells across developmental stages and discovered that a histone methyltransferase SETD1B establishes thousands of spermatid-specific broad H3K4me3 domains to ensure temporal transcriptional control during sperm development.

https://doi.org/10.1038/s41422-025-01104-9

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