Volume 35, No 5, May 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 5, May 2025: 326-327

RESEARCH HIGHLIGHTS

Identification of a GPCR as a tip link-independent equilibrioceptor

Biyun Zhu^{1,2,3,4,5,†} , Shao Wei Hu^{1,2,3,4,5,†} , Yilai Shu^1,2,3,4,5,*

¹ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China
²NHC Key Laboratory of Hearing Medicine, Shanghai, China
³State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
⁴Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⁵Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, China
^†These authors contributed equally: Biyun Zhu, Shao Wei Hu
Correspondence: Yilai Shu(yilai_shu@fudan.edu.cn)

The sense of balance, mediated by the vestibular system, is crucial in our three-dimensional world. In a recent study published in Cell Research, Yang et al. revealed an essential role of a mechanosensitive G protein-coupled receptor as a tip link-independent equilibrioceptor actively participating in the mechano-electrical transduction process.

https://doi.org/10.1038/s41422-025-01102-x

FULL TEXT | PDF

Browse 209