Volume 35, No 9, Sep 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 9, September 2025: 625-626

RESEARCH HIGHLIGHTS

Phase separation paints Xi with Xist

Thomas C. T. Michaels^1,2,* , Anton Wutz^3,*

¹Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
²Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland
³Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology ETH Hönggerberg, Zurich, Switzerland
Correspondence: Thomas C. T. Michaels(thomas.michaels@bc.biol.ethz.ch)Anton Wutz(awutz@ethz.ch)

In a recent study, Ding et al. investigated the role of hnRNPK phase separation in mammalian dosage compensation. The study stands out by linking biophysical and biochemical measurements with genetic and cell biological experimentation, providing wide-ranging evidence for specific mechanistic aspects of X chromosome inactivation, while expanding the potential repertoire for phase separation in biology.

https://doi.org/10.1038/s41422-025-01116-5

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