Volume 35, No 7, Jul 2025
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 35 Issue 7, July 2025: 520-523 | Open Access
LETTERS TO THE EDITOR
Pyrimidine synthase CAD deamidates and inactivates p53
Yue Qi1,† , Zizheng Tan2,† , Hanyu Chen1 , Ziqi Xiao2 , Liang Zhang1 , Boxuan Wu2 , Chennan Liu2 , Yunqian Gao3 , Xueyan Yang1 , Lingqian Wu4 , Lei Lu2,* , Hongyan Wang1,2,5,*
1Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children’s Hospital, Fudan University, Shanghai, China
2Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China
3Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
4The Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China
5Prenatal Diagnosis Center of Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, Guangzhou, China
†These authors contributed equally: Yue Qi, Zizheng Tan
Correspondence: Lei Lu(lulei@fudan.edu.cn)Hongyan Wang(wanghy@fudan.edu.cn)
https://doi.org/10.1038/s41422-025-01112-9
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