Volume 35, No 6, Jun 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 6, June 2025: 395-396

RESEARCH HIGHLIGHTS

Orchestrating NTSR1 signaling from the interface

Xianglin Huang , Brian E. Krumm , Bryan L. Roth^*

Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA
Correspondence: Bryan L. Roth(bryan_roth@med.unc.edu)

Biased allosteric modulators provide great therapeutic potential by selectively directing signal bias in the presence of endogenous ligand under (patho)physiological conditions. In a recent Cell Research paper, Sun et al. revealed the structural mechanisms underlying the biased allosteric modulation exerted by SBI-533 directly at the neurotensin receptor 1–β-arrestin1 interface.

https://doi.org/10.1038/s41422-025-01121-8

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