Volume 35, No 6, Jun 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 6, June 2025: 389-390

RESEARCH HIGHLIGHTS

Targeting an alternative route: autophagy in RAS-driven cancers

Alina Üffing , Eleanor Attridge , Sharon A. Tooze^*

The Francis Crick Institute, 1 Midland Road, London, UK
Correspondence: Sharon A. Tooze(Sharon.tooze@crick.ac.uk)

Activating RAS mutations have been linked to overactivation of autophagy but how this can be differentiated from physiological autophagy is poorly understood. Wang and colleagues reveal a RAS-induced non-canonical mechanism of autophagy and propose a promising new target against RAS-mutant cancers.

https://doi.org/10.1038/s41422-025-01127-2

FULL TEXT | PDF

Browse 77