Volume 35, No 12, Dec 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 12, December 2025: 926-927

RESEARCH HIGHLIGHTS

Gut microbiota fuels clonal hematopoiesis

Francisco Caiado , Markus G. Manz^*

Department of Medical Oncology and Hematology, University and University Hospital Zürich, Zürich, Switzerland
Correspondence: Markus G. Manz(markus.manz@usz.ch)

Clonal hematopoiesis of indeterminate potential (CHIP) is a frequent health-debilitating condition resulting from progressive, age-dependent expansion of mutant hematopoietic stem and progenitor cells. In a recent Nature paper, Agarwal et al. show that aging associates with increased gut permeability and consequent higher circulating levels of a microbiota-derived metabolite, ADP-heptose, which upon engaging its receptor ALPK1, favors the clonal expansion of CHIP-mutant hematopoietic stem cells.

https://doi.org/10.1038/s41422-025-01137-0

FULL TEXT | PDF

Browse 225