Volume 35, No 8, Aug 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 8, August 2025: 610-613

LETTERS TO THE EDITOR

Phrixotoxin-3 binds to three distinct antagonistic sites on human Na_v1.6

Xiao Fan^1,7,† , Jiaofeng Chen^2,† , Xiaoshuang Huang³ , Zhanfeng Hou⁴ , Yuzhen Xie³ , Zigang Li^4,5 , Nieng Yan^2,3,6,* , Jian Huang^3,*

¹Department of Molecular Biology, Princeton University, Princeton, NJ, USA
²Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
³Institute of Bio-Architecture and Bio-Interactions (IBABI), Shenzhen Medical Academy of Research and Translation, Guangming District, Shenzhen, Guangdong, China
⁴State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China
⁵Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China
⁶Institute of Chemical Biology, Shenzhen Bay Laboratory, Guangming District, Shenzhen, Guangdong, China
⁷Present address: Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, USA
^†These authors contributed equally: Xiao Fan, Jiaofeng Chen
Correspondence: Nieng Yan(nyan@tsinghua.edu.cn)Jian Huang(huangjian@smart.org.cn)

https://doi.org/10.1038/s41422-025-01141-4

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