Volume 35, No 12, Dec 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 12, December 2025: 932-933

RESEARCH HIGHLIGHTS

Antibiotics deliver a gut punch to infant immunity

Brian D. Rudd^*

Department of Microbiology & Immunology, Cornell University, Ithaca, NY, USA
Correspondence: Brian D. Rudd(bdr54@cornell.edu)

The development of the immune system is known to be shaped by the microbiota and their metabolites, yet the key players are poorly understood. Stevens and colleagues now show that microbiota-derived inosine is an important regulator of CD8⁺ T cell immunity in early life, opening up new therapeutic opportunities to protect infants from severe viral infections.

https://doi.org/10.1038/s41422-025-01158-9

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