Volume 35, No 9, Sep 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 9, September 2025: 629-641   |  Open Access

REVIEW ARTICLE

A decade of migrasome research: biogenesis, physiological functions, and disease implications

Jinqiang Yu^1,2,3 , Li Yu^1,2,3,4,*

¹State Key Laboratory of Membrane Biology, Beijing, China
²Beijing Frontier Research Center for Biological Structure, Beijing, China
³School of Life Sciences, Tsinghua University, Beijing, China
⁴Tsinghua University–Peking University Joint Center for Life Sciences, Beijing, China
Correspondence: Li Yu(liyulab@mail.tsinghua.edu.cn)

Since their first report a decade ago, our understanding of migrasomes — specialized organelles initially identified in migrating cells—has advanced considerably. Researchers have elucidated key aspects of migrasome biology, including the mechanisms of their biogenesis, their roles in cellular physiology, and their implications in various diseases. Concurrently, the development of a robust toolkit for migrasome analysis has transformed these structures from mere microscopy curiosities into central players in an emerging field with significant impact on cell biology, developmental biology, immunology, and disease pathology. This review provides a comprehensive summary of current insights into migrasome biology, with a particular focus on the molecular mechanisms governing their formation and their established cellular and physiological functions. In addition, we highlight the current challenges and unresolved

https://doi.org/10.1038/s41422-025-01153-0

FULL TEXT | PDF

Browse 66