Volume 35, No 10, Oct 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 10, October 2025: 695-696

RESEARCH HIGHLIGHTS

Cultured human stem cells undergoing gastrulation

Fan Zhang^1,2 , Fan Guo^1,2,*

¹State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, Chin
²Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China
Correspondence: Fan Guo(guofan@ioz.ac.cn)

In a recent study published in Cell Research, Huang et al. established human gastrulating stem cells (hGaSCs), a stable in vitro population capable of differentiating into multiple gastrulating lineages. These cells self-organize into embryo-like structures both in vitro and in vivo, offering an ethically viable platform for modeling early human development and assessing drug teratogenicity.

https://doi.org/10.1038/s41422-025-01151-2

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