Volume 35, No 10, Oct 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 10, October 2025: 699-700

RESEARCH HIGHLIGHTS

Novel organoid culture condition: modeling fetal-like plasticity in colorectal cancer

Chao Wu¹ , Min Jung Kim¹ , J. Joshua Smith^2,*

¹Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
²Department of Colon and Rectal Surgery, MD Anderson Cancer Center, Houston, TX, USA
Correspondence: J. Joshua Smith(JJSmith5@mdanderson.org)

A recent study published in Cell Research established a new condition for patient-derived organoid (PDO) culture. The PDO enables long-term expansion and maintenance with fetal-like features, preserves the oncofetal-like state, and reveals FGF2-AP-1 signaling associated with phenotypic plasticity and increased treatment resistance.

https://doi.org/10.1038/s41422-025-01170-z

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