Volume 35, No 10, Oct 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 10, October 2025: 697-698

RESEARCH HIGHLIGHTS

Osteocalcin has many tricks to get γ-carboxylated

Correspondence: 0

Osteocalcin is a bone-derived hormone whose bioactivity is regulated by vitamin K-dependent γ-carboxylation. Using cryo-electron microscopy, Cao et al. elucidate the structure of the osteocalcin precursor bound to the vitamin K-dependent γ-carboxylase, revealing unique and complex interactions between the enzyme and its substrate.

https://doi.org/10.1038/s41422-025-01177-6

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