Volume 36, No 1, Jan 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 1, January 2026: 9-10

RESEARCH HIGHLIGHTS

APOL proteins tune gut immunity via commensal lipid recognition

Shohei Asami^* , Hiroshi Ohno^*

Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Tsurumi, Yokohama, Japan
Correspondence: Shohei Asami(shohei.asami@riken.jp)Hiroshi Ohno(hiroshi.ohno@riken.jp)

In a recent paper published in Nature, Yang and colleagues identified a novel lipid–protein interaction that broadly regulates the behavior of dominant gut bacteria from the Bacteroides taxa. This interaction, in turn, tunes the expression of immune-regulating molecules in intestinal epithelial cells and promotes the expansion of specialized immune cells important for gut health.

https://doi.org/10.1038/s41422-025-01166-9

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