Volume 35, No 11, Nov 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 11, November 2025: 783-784

RESEARCH HIGHLIGHTS

Deconstructing the architecture of memory engrams

Yi Zhong^1,* , Bo Lei²

¹School of Life Sciences, Tsinghua University, Beijing, China
²Beijing Academy of Artificial Intelligence, Beijing, China
Correspondence: Yi Zhong(zhongyithu@tsinghua.edu.cn)

From “grandmother cell” to engram cells, memory theories have evolved over the last century from finding the engram to deconstructing its internal architecture. Recent studies suggest that engram cells are not uniform, but instead contain subpopulations defined by distinct immediate early genes such as c-Fos and Npas4; Jin et al. now reveal molecular differences between these ensembles, providing a new molecular perspective on the architecture of memory engrams.

https://doi.org/10.1038/s41422-025-01179-4

FULL TEXT | PDF

Browse 101