Volume 35, No 11, Nov 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 11, November 2025: 785-786

RESEARCH HIGHLIGHTS

LGP2 stops MDA5 translocation to start antiviral signaling

Jiyoung Jang , Myung Hyun Jo^*

Department of Life Sciences, Korea University, Seoul, South Korea
Correspondence: Myung Hyun Jo(mhjo@korea.ac.kr)

In a recent study published in Cell Research, Han et al. revealed that MDA5, a member of the RIG-I-like receptor family, translocates along dsRNA to form dynamic ATP-dependent mobile clusters, which suppress spontaneous filament assembly and aberrant activation. LGP2 can halt MDA5 movement and assemble MDA5 clusters into signaling-competent filaments required for MAVS activation, which is a mechanism essential for preventing uncontrolled responses.

https://doi.org/10.1038/s41422-025-01187-4

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