Volume 35, No 12, Dec 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 12, December 2025: 922-923

RESEARCH HIGHLIGHTS

KCNQ1 and PIP₂: it takes two to tango

Alicia De La Cruz , H. Peter Larsson^*

Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
Correspondence: H. Peter Larsson(Peter.Larsson@liu.se)

The KCNQ1 potassium channel plays important roles in many physiological systems, such as heart beating and hearing. Here in two articles in Cell Research, Cui et al. and Zhong et al. present structures of KCNQ1 in the presence of the important KCNE1 subunit and PIP2 to show structural rearrangements induced by KCNE1 and that KCNQ1 requires two bound PIP2 molecules per subunit to open.

https://doi.org/10.1038/s41422-025-01189-2

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