Volume 35, No 12, Dec 2025

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 35 Issue 12, December 2025: 1079-1082

LETTERS TO THE EDITOR

Nearly complete redirection of insertion-type indel into recombination enhances knock-in and facilitates endogenous biomolecular condensate analysis

Minglei Huang^1,2,† , Jingjing Fu^1,2,† , Peizhe Wang^1,2,† , Boyi Chen^2,† , Qichen Yuan^1,2,† , Jiawei Yu^1,2 , Huimin Wang³ , Yiting Liu² , Zhiyi Li^1,2 , Yanling Wu⁴ , Tianlei Ying⁴ , Qingfeng Wu⁵ , Ming Zhu^2,* , Wei Qin^2,6,* , Yinqing Li^1,2,*

¹IDG/McGovern Institute for Brain Research, State Key Laboratory of Molecular Oncology, MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China
²School of Pharmaceutical Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China
³School of Basic Medical Sciences, Tsinghua University, Beijing, China.
⁴MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China
⁵State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⁶TsinghuaPeking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, The State Key Laboratory of Membrane Biology, Tsinghua University, Beijing, China
^†These authors contributed equally: Minglei Huang, Jingjing Fu, Peizhe Wang, Boyi Chen, Qichen Yuan
Correspondence: Ming Zhu(zhu-m16@tsinghua.org.cn)Wei Qin(weiqin@tsinghua.edu.cn)Yinqing Li(yinqingl@tsinghua.edu.cn)

https://doi.org/10.1038/s41422-025-01190-9

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