Volume 36, No 3, Mar 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 3, March 2026: 177-178

RESEARCH HIGHLIGHTS

ZBP1 links infections to cancer immunotherapy

Lorenzo Galluzzi^1,* , Spencer Brackett¹ , Neil Johnson^2,*

¹Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA
²Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, USA
Correspondence: Lorenzo Galluzzi(deadoc80@gmail.com)Neil Johnson(neil.johnson@fccc.edu)

Z-DNA binding protein 1 (ZBP1) was thought to initiate necroptotic cell death in response to viral Z-RNA molecules. Recent data demonstrate that viral infection causes the accrual of endogenous Z-RNA species that are sufficient for ZBP1-driven necroptosis, opening the road to therapeutic strategies aimed at maximizing the immunogenicity of cancer cell death via necroptosis.

https://doi.org/10.1038/s41422-025-01196-3

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